Synchrotron radiation in a chromo-magnetic field

We study the generalization of QED synchrotron radiation to the QCD case with a chromomagnetic field using the Schwinger {\it et al} source method. It is shown that the QED case can be obtained as a special limit. The comparison with the path integral approach of Zakharov has shown consistent results.Comment: Accepted for publication in Phys. Rev.

How proteins bind macrocycles

The potential utility of synthetic macrocycles (MCs) as drugs, particularly against low-druggability targets such as protein-protein interactions, has been widely discussed. There is little information, however, to guide the design of MCs for good target protein-binding activity or bioavailability. To address this knowledge gap, we analyze the binding modes of a representative set of MC-protein complexes. The results, combined with consideration of the physicochemical properties of approved macrocyclic drugs, allow us to propose specific guidelines for the design of synthetic MC libraries with structural and physicochemical features likely to favor strong binding to protein targets as well as good bioavailability. We additionally provide evidence that large, natural product-derived MCs can bind targets that are not druggable by conventional, drug-like compounds, supporting the notion that natural product-inspired synthetic MCs can expand the number of proteins that are druggable by synthetic small molecules.R01 GM094551 - NIGMS NIH HHS; GM064700 - NIGMS NIH HHS; GM094551 - NIGMS NIH HHS; R01 GM064700 - NIGMS NIH HHS; GM094551-01S1 - NIGMS NIH HH

Lorentz Transformation from Symmetry of Reference Principle

The Lorentz Transformation is traditionally derived requiring the Principle of Relativity and light-speed universality. While the latter can be relaxed, the Principle of Relativity is seen as core to the transformation. The present letter relaxes both statements to the weaker, Symmetry of Reference Principle. Thus the resulting Lorentz transformation and its consequences (time dilatation, length contraction) are, in turn, effects of how we manage space and time.Comment: 2 page

Laparoscopic intraperitoneal on-lay mesh repair for the umbilical hernia using anti-adhesive gel

Curs Chirurgie Generală al Facultăţii Stomatologie, USMF „Nicolae Testemiţanu”, Spitalul Clinic Militar Central, Chişinău, Republica Moldova, Al XII-lea Congres al Asociației Chirurgilor „Nicolae Anestiadi” din Republica Moldova cu participare internațională 23-25 septembrie 2015Introducere: Poziţionarea intraperitoneală a plasei chirurgicale în cadrul curei laparoscopice intraperitoneale (IPOM) impune selectarea materialului sintetic. Material şi metode: În clinica noastră de chirurgie (SCMC), în anii 2013-2015 au fost supuşi curei laparoscopice pentru hernie ombilicală 10 pacienţi, 6 femei şi 4 bărbaţi. Vârsta a variat de la 20 pînă la 60 ani. Pentru protezare s-a folosit plasa din polivinilidenftorid (PVDF) de tip „Uniflex” (Rusia), mai mare cu 5 cm decât defectul herniar pe toate dimensiunile. Pentru prevenirea aderenţelor parieto-viscerale a fost utilizat suplimentar, compozitul antiadeziv „Mezogel” (Rusia). Fixarea plasei s-a asigurat prin aplicarea a 5 suturi tip „ancore” transfasciale şi agrafe helicoidale neresorbabile de diametrul – 4 mm, plasate la 1cm de marginea protezei. Algometria s-a efectuat cu utilizarea scalei analog vizuale (VAS). Rezultate: Defectul herniar a avut un diametru median de 3,9 cm. La 4 pacienţi a fost suturat defectul (diametrul = 1-3 cm) herniar prin aplicarea suturii intracorporale. Din particularităţi intraoperatorii se menţionează: reducerea conţinutului sacului herniar, adezioliză, controlul hemoragiei din adeziuni. Durata medie a intervenţiilor a fost de 55 min (45-65 min). În perioada postoperatorie complicaţii nu au fost semnalate. Sindromul dolor postoperator a fost minim (VAS: 1-3); complicaţii parietale – absente. Durata mediană de spitalizare – 3,2 zile. În perioada postoperatorie la distanţă nu s-au constatat dureri şi neuropatii, dereglări de tranzit intestinal sau recidive herniare. Concluzii: Cura laparoscopică a herniei ombilicale cu aplicarea protezei IPOM este o metodă fezabilă, sigură şi minim-invazivă. Plasa şi gelul cu proprietăţi antiadezive reduce semnificativ riscul aderenţelor parieto-viscerale şi a complicaţiilor parietale, asigurând reintegrarea socio-profesională rapidă. Avantajele expuse argumentează perspectivele utilizării tehnicii IPOM în cura herniilor ombilicale.Introduction: In laparoscopic intraperitoneal on-lay mesh repair (IPOM) positioning of a surgical mesh requires the selection of a synthetic material with anti-adhesive properties. Material and methods: Within period of 2013-2015, 10 IPOM hernia repairs have been performed on the group of 10 patients diagnosed with umbilical hernia, 6 male and 4 female. The overall age was 36.4 years (range 20-60). The PVDF monofilament macroporous mesh has been utilized for repair. The mesh overlaped the defect with 5 cm. The combined fixation technique was ensured by applying the “anchor” type sutures and 4 mm non-resorbable spiral tacks plaid up to 1 cm from the edge of the prosthetic mesh. The non-adhesive composite “Mezogel” has been used to ensure the prevention of the adhesions. Algometry was performed using visual analog scale (VAS). Results: The mean diameter of the hernia defect was 3.9 cm. In 4 cases the hernia defect (d=1-3 cm) has been closed by applying intracorporeal suture. The intraoperative features were: reduction the hernia sac content, removal of adhesions, control of the bleeding. The mean time of operations was 55 min. In postoperative period there no reported complications. In the distance postoperative period were not found pain and local neuropathy, bowel disorders or hernia recurrences. Conclusions: Laparoscopic IPOM umbilical hernia repair it is a feasible, safe and minimally-invasive procedure. Prosthesis and gel with anti-adhesive properties significantly reduce the risk of the parieto-visceral adhesions and complications ensuring quick socio-professional reintegration. The exposed advantages arguments the use of IPOM procedure in the umbilical hernia repair

An integrated brain-behavior model for working memory.

Working memory (WM) is a central construct in cognitive neuroscience because it comprises mechanisms of active information maintenance and cognitive control that underpin most complex cognitive behavior. Individual variation in WM has been associated with multiple behavioral and health features including demographic characteristics, cognitive and physical traits and lifestyle choices. In this context, we used sparse canonical correlation analyses (sCCAs) to determine the covariation between brain imaging metrics of WM-network activation and connectivity and nonimaging measures relating to sensorimotor processing, affective and nonaffective cognition, mental health and personality, physical health and lifestyle choices derived from 823 healthy participants derived from the Human Connectome Project. We conducted sCCAs at two levels: a global level, testing the overall association between the entire imaging and behavioral-health data sets; and a modular level, testing associations between subsets of the two data sets. The behavioral-health and neuroimaging data sets showed significant interdependency. Variables with positive correlation to the neuroimaging variate represented higher physical endurance and fluid intelligence as well as better function in multiple higher-order cognitive domains. Negatively correlated variables represented indicators of suboptimal cardiovascular and metabolic control and lifestyle choices such as alcohol and nicotine use. These results underscore the importance of accounting for behavioral-health factors in neuroimaging studies of WM and provide a neuroscience-informed framework for personalized and public health interventions to promote and maintain the integrity of the WM network